The Quadripartite Global Integrated Surveillance Systems for Antimicrobial Resistance and Use, known as GISSA, encompasses the actions and activities of the Quadripartite organizations concerning One Health integrated surveillance of AMR and AMU. It is an overarching framework that brings together all related activities, initiatives, and projects under a single umbrella. Through this central coordination, GISSA ensures a unified approach to tackling AMR and AMU across various sectors, strengthening the effectiveness of integrated surveillance worldwide.